The case of a homosexual patient sent to a psychology service for depressive-anxious symptoms is described. The patient had adopted an avoidance coping and a passive-anassertive attitude towards his sexual orientation, especially due to the shame deriving from a self-stigma. He had a brother who was married with three children and died 3 years earlier. The trans-diagnostic framework of the clinical case leads to the identification of short, medium and long-term therapeutic objectives such as: immediate psychological support, and then, once the mood had improved, reduction self-stigma for HIV, internalized homophobia, and then the coping with social problems and avoidance behaviors. Recognizing that his avoidance behaviors have been learned in the family context, psychotherapy proceeded rapidly, especially since the patient has started making decisions in his favor and following his preference. Today he has moved to a new home where he lives happily, he also bought a new car and meets a man he has been dating for a few months.